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The evolution of semiconductor-based radios has allowed the rapid development of RF Design both for wireless systems and wireless modules. One advantage of semiconductor integration is the ability to realize various radio systems as differential circuits to maximize performance and yield. However, many wireless systems are single-ended at the front-end terminals. Regardless if the interface is single-ended or differential, it is important to understand the characteristics of a single differential RF port in terms of Mixed-Mode S-parameters in order to bridge the two disciplines of RF design engineering and semiconductor engineering.

If you would like to read the rest, it can be found here: http://info.lsr.com/LSR-Wireless-RF-Design-blog/bid/215793/RF-Design-using-Differential-S-parameters-for-Wireless-Modules